This review article summarizes key evidence from the HarvestPlus program on how biofortification has helped improve nutrition worldwide between 2003 and 2016. Delivery experiences in various target countries (Bangladesh, DR Congo, India, Nigeria, Pakistan, Rwanda, Uganda, and Zambia) are discusses, as well as farmer and consumer adoption. According to the authors, attention should now shift to an action-oriented agenda for scaling biofortification to improve nutrition globally. »